In the laboratory pure water industry, high-end pure water systems often come equipped with TOC (Total Organic Carbon) detection to monitor and control organic contamination levels and ensure that the quality of the pure water meets relevant standards. The most common TOC detection technology used in these systems is ultraviolet (UV) oxidation. Currently, two primary methods are employed for TOC detection: complete oxidation and partial oxidation.

Pure water systems that utilize partial oxidation for TOC measurement offer a viable option for certain applications. This method provides a general indication of organic contamination levels. However, it’s important to acknowledge that partial oxidation may not fully convert all organic compounds into carbon dioxide, the target analyte for TOC detection. Consequently, partial oxidation TOC detection results may not provide a complete picture of organic contamination levels.

For users with high water purity requirements, such as those adhering to USP standards, it is strongly recommended that they opt for pure water systems featuring TOC detection modules designed with complete oxidation technology.

RephiLe’s pure water TOC detection technology employs a complete oxidation approach, ensuring full compliance with USP requirements. This method ensures that all organic compounds are completely converted into carbon dioxide, providing accurate and reliable TOC monitoring.

• Enhanced Accuracy: Complete oxidation ensures the accurate detection of all organic compounds, meeting the stringent standards of the USP.
• USP Compliance: Complete oxidation TOC detection technology guarantees compliance with USP regulations, making it the ideal choice for pharmaceutical and biotechnology applications.
• Reliable Performance: The robust and reliable nature of complete oxidation TOC detection provides consistent and dependable results, minimizing the risk of inaccurate measurements.

RephiLe ultrapure water systems, featuring complete oxidation TOC detection, are designed to meet the critical requirements of various industries, including pharmaceuticals, biotechnology, and healthcare.  

The following RephiLe water systems (introduced to the market after 2018) are standard with a TOC measurement:

• Genie G, Large Genie G and Super-Genie G – systems produce Type I ultrapure water and Type II EDI pure water from tap water;
• Large Genie U and Super-Genie U – systems produce Type I ultrapure water and RO pure water from tap water.

Users of the following systems may optionally install an online TOC monitoring system-

• Genie U – For type I ultrapure water and RO pure water from tap water;
• Genie A – For type I ultrapure water and RO pure water from tap water, no storage tank needed;
• Genie PURIST – For type I ultrapure water from purified water (RO, EDI, deionized and distilled water)

About RephiLe & Duoning:

RephiLe, Revolution in Filtration. RephiLe Bioscience designs and manufactures innovative and high-quality purification-based products for biotechnology and life science laboratories. Our offering includes laboratory ultrapure water systems, replacement consumables, and other filtration products. It is RephiLe’s commitment to helping our customers beyond the products which we manufacture.

Duoning is a one-stop solution provider in the field of the biopharmaceutical industry and laboratories. With an integrated product portfolio covering almost all major steps of biopharmaceutical manufacturing including plasmid construction, production of adeno-associated (AAV) vectors, and mRNA vaccines, Duoning aims to enhance customers’ productivity by offering fast and effective tools from bench through bioprocess production.